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Choose to edit a file and then right click the file on the transfer queue and go to Properties. Click the "Select File" button to the right of the local directory section and choose the new file you want to use for the source and hit OK on the properties box. Now if you go and edit the file that you chose as the new source file and save it, it won't be picked up by SmartFTP. To get it to start monitoring the correct file, you have to stop the transfer queue and start it up again, and then from there on it will start monitoring the correct file.